2026-04-17T17:40:21.469Z http://ezaposleni.singidunum.ac.rs/rest/sciNaucniRezultati/oai

ezaposleni.singidunum.ac.rs/rest/sciNaucniRezultati/oai:2:7238 2024-06-29T21:34:54Z 2

Relationship Between Occupational Physical Activity and Subclinical Vascular Damage in Moderate-Altitude Dwellers 2017 http://ezaposleni.singidunum.ac.rs/rest/sciNaucniRezultati/oai/record/2/7238 K. Ujka R. Bruno L. Bastiani E. Bernardi P. Sdringola N. Dikić B. Basyal S. Bhandari B. Basnyat A. Cogo L. Pratali Background: Occupational physical activity (OPA) has been associated with increased cardiovascular (CV) events. The aim of this study was to investigate the association between OPA and markers of subclinical vascular damage among a moderate-altitude population living in the rural village of Chaurikharka (Nepal; 2600m sea level). Methods: Seventy-two individuals (age 42 – 15 years, ranges 15–85 years, 23 men) were enrolled. Physical activity (PA) was evaluated using the International Physical Activity Questionnaire (IPAQ). Carotid–femoral pulse wave velocity (PWV), carotid ultrasound assessment, and flow-mediated dilation (FMD) were performed. Results: OPA was 9860 – 5385 Metabolic Equivalent of Task (MET)-minutes/week, representing 77% of total energy expenditure, with 97% of the population performing high-intensity PA. In the univariate analysis, OPA was significantly associated with PWV (b = 0.474, p = 0.001) and carotid stiffness (CS) (b = 0.29, p = 0.019). In the multivariate analysis, including age, sex, oxygen saturation, mean blood pressure, low-density lipoprotein (LDL), and OPA, OPA remained an independent predictor of PWV (b = 0.403, p = 0.001) but not of CS (b = 0.028, p = 0.8). OPA remained an independent predictor of PWV independently from the Framingham risk score (FRS). Conclusion: High-intensity OPA shows a positive, independent association with aortic stiffness in Himalayan moderate-altitude dwellers. This study suggests how vigorous OPA performed in moderate altitude may be a CV risk factor. article 18 249 257 1527-0297 HIGH ALTITUDE MEDICINE & BIOLOGY